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Animal Model and Ethics Statement Wistar rats from the breeding colony at the Universidade do Extremo Sul Catarinense (UNESC), Brazil, were housed four times per cage under controlled conditions of temperature (22 1 C), relative humidity (4555%) and light-dark cycle (12:12 p.m., light on at 6 a.m.)
6 and 7 i and ii)
Modified melasma area and severity index (MASI) score was calculated before and after therapy
Reconstitution concentration is user-defined
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