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Soorya et al 73
Whilst vitamin B12 toxicity is exceptionally rare due to its water-soluble nature, very high levelsparticularly from mega-dose supplements or frequent injectionshave been associated with certain adverse effects, most notably skin reactions
Mutant OPTN promotes the expression of downstream target genes of NF-B, such as p53 and proapoptotic proteins, to induce cell death by triggering p53-dependent apoptosis
Metabolic instruction of immunity
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