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While initially regarded as a tumor suppressor for its ability to inhibit canonical Wnt/-catenin signaling by binding to low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6), recent research has revealed that DKK1 can also promote tumor growth by influencing MDSCs and the immune microenvironment [164]
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doi:10.4103/2152-7806.85609
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