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It has been reported that the deficiency of TFEB increased the mitochondrial ROS production and exacerbate tubular injury during CP renal injury (Lynch et al., 2020)
They were originally developed and approved for type-2 diabetes management but have more recently gained regulatory approval in several markets for obesity treatment as well
This medication is taken once daily on an empty stomach, at least 30 minutes before the first food, beverage, or other oral medication of the day
However, the medication's gastrointestinal side effectsparticularly nausea, vomiting, and diarrhoeacan potentially lead to dehydration, a well-recognised risk factor for kidney stones
