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This approach aligns with clinical evidence showing that slower dose escalation produces fewer dropouts due to intolerance
Starting doses typically begin low and gradually increase over several weeks to minimize gastrointestinal side effects like nausea, which are the most common complaint during the first few weeks of treatment
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doi: 10.3389/fcvm.2026.1708109 Received 18 September 2025 Revised 16 January 2026 Accepted 19 January 2026 Published 05 March 2026 Volume 13 - 2026 Edited by Rui Providencia, University College London, United Kingdom Reviewed by Marinela Couselo Seijas, Spanish National Centre for Cardiovascular Research, Spain Toluwalase Awoyemi, University of Oxford, United Kingdom Updates Copyright 2026 Liu and Lu
