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However, this efficacy came with trade-offs
The model of CTR: rAmy (CT-like, PDB: 7TYI) was used as the initial template for the CTR:Cagri/CagriBB complex in the CT-like conformation by replacement of the peptide
On June 4, 2021, the FDA approved the use of semaglutide for weight loss and long-term weight management under the brand name Wegovy
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