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We can build on that understanding by noting that bile acids moving through the digestive tract stimulate GLP-1 secretion (2)

It was that knowledge of glucagon sequence, and its biologywhich actually was very critical for my discovery of GLP-1. Originally thought to be simply responsible for triggering insulin secretion by the pancreas, scientists soon discovered that the hormone also inhibits glucagon secretion by the pancreas and delays gastric emptying

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In the context of autoimmunity, the most relevant are those that influence T-cell differentiation, cytokine production, inflammatory signaling pathways, and immune cell communication