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Contraindications or require Caution: individuals who are pregnant or breastfeeding, active malignancy (cancer), untreated hypothyroidism, intracranial lesions/tumors, and acute critical illness
Recommending unapproved treatments undermines this principle and puts patients at unnecessary risk
However, at this time, the only legitimate way to access retatrutide is through participation in an authorized clinical trial
Induction is problematic in drug development and an undesirable characteristic for a drug, thus drugs that have Phase II metabolism as their primary route of elimination may be easier to develop
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