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Yes, semaglutide has one of the longest half-lives among GLP-1 medications

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Biochemical profile of propionyl-L-carnitine [PMID: 2031874] Laboratory literature summary: Biochemical profile of propionyl-L-carnitine

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As you can see, those on placebo or the three smallest doses of semaglutide lost between 0.8 kg and 2.0 kg during the 12-week study with no statistically significant differences across these groups

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