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658 Regular transfusions are associated with long-term complications, especially iron overload, typically requiring iron chelation therapy
There was a correlation between decreased complex I activity and increased protein oxidation (measured by protein carbonylation, and levels of 3-nitrityrosine) when investigating postmortem prefrontal cortex brains from BD affected and non-affected individuals [48]
In preclinical studies, healthy mice, CKD rats, and diabetic mice treated with NA, NAM, or NMN showed increased NAD + levels in the kidney 297,298,299
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