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The PepT1 (SLC15A1) transporter a proton-coupled oligopeptide transporter normally expressed in the small intestine is dramatically upregulated in the colon during inflammatory bowel disease

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It is also effective for neuropathy, delayed wound healing, scurvy, and symptoms like weakness, fatigue, and reduced immunity caused by vitamin deficiencies

Mechanistically, this was associated with increased expression/internalization of VEGFR2 and activation of downstream Akt-eNOS signaling (Hsieh 2017)