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Causes and Risk Factors (Why You Got It) Common triggers - A viral upper respiratory infection that leads to secondary bacterial infection - Allergies that inflame and block nasal passages - Structural issues (deviated septum, nasal polyps) - Smoke/irritants and poor air quality Why inflammation matters: inflammation narrows drainage pathways

Acknowledgements This research was supported by National Key R&D Program of China (2021YFF0702600), the National Natural Science Foundation of China (82222056 and 82111530099), Guangdong Special Young Talent Plan of Scientific and Technological Innovation (2019TQ05Y510), the Natural Science Foundation of Guangdong (2022A1515012316), the Guangdong International Joint Research Program (2020A0505100027), and National Key Clinical Discipline

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Journal of Physiology Paris 93:501504 Radeljak S, Seiwerth S, Sikiric P (2004) BPC 157 inhibits cell growth and VEGF signalling via the MAPK kinase pathway in the human melanoma cell line