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Future large-scale, long-term, and population-diverse clinical studies are warranted to refine safety profiles, establish optimal intake strategies, and facilitate the evidence-based integration of shiitake mushrooms into functional foods, dietary guidelines, and public health interventions aimed at improving human health outcomes
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Previous strategies to overcome these barriers, including dose optimization, image-guided planning, and combination systemic therapy, have achieved only incremental gains, leaving a significant unmet clinical need for innovative, tumor-targeted solutions [18, 19]
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