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It wastes months of effort, creates unnecessary side effects, and delays the results you actually want
Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)
A rhein-based derivative targets Staphylococcus aureus
Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
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