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At the cellular level, receptor recycling begins within hours of reduced agonist exposure, but full receptor density restoration requires complete drug clearance first
The article underscores that the development has its basis in scientific studies on pathophysiology of type 2 diabetes and the importance of targeting the islet dysfunction, that the development has been made possible through academic science in collaboration with the research-oriented pharmaceutical industry, and that the development of a novel concept takes time and requires focused efforts, persistence and long-term perserverance
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