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* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies ** Based on the treatment policy estimand: estimated efficacy regardless of whether patients stayed on treatment or took other weight loss therapies About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program)

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Additional benefits include metabolic enhancement without growth hormone side effects, no impact on blood glucose or insulin sensitivity, potential increases in energy expenditure through thermogenic mechanisms, and compatibility with athletic training and performance goals

Pathway-level genetic context is the upstream variable underneath every protocol choice