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In the Phase 2 trial published in the New England Journal of Medicine (2023), retatrutide was administered as a once-weekly subcutaneous injection using a structured dose-escalation schedule
Indications Dysbiosis, diabetes, obesity, hypercholesterolemia, hyperlipidemia, and inflammatory bowel disease
The mean differences between the treatment and placebo groups were approximately 12 centimeters across the two trials. The trials also reported: Mean trunk-fat reductions of approximately 0.81.0 kilograms Mean lean-body-mass increases of approximately 1.21.3 kilograms Little overall change in total body weight These results suggest that tesamorelin can alter the distribution of fat and lean tissue without functioning as a conventional weight-loss agent
It can also be taken as a supplement as a liposomal formulation or in the form of S-acetyl-glutathione, although these also appear to have limited impact on raising glutathione levels in the body
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