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The oral route of administration pose challenges due to the drugs high molecular weight, extremely low absorption with the commercially available oral tablets and the drugs sensitivity to the heat required to compound it into a lozenge

There is some research showing a link including: SIBO incidence Case reports of diagnosed SIBO after starting semaglutide or tirzepatide Slowed motility Studies showing slowed gut motility and increased bacterial overgrowth in healthy controls and patients with IBS

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Small, frequent meals, avoiding high-fat or spicy foods, maintaining good hydration, and following the gradual dose escalation schedule can help manage these effects