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(4) showed that knocking down Bmal1 (one of the essential clock genes that participate in the maintenance of the circadian periodicity at the cellular level) in mice suprachiasmatic nucleus (SCN) led to increased escape latencies and number of escape failures in the learned helplessness paradigm, induced higher immobility time in the tail suspension test, and decreased the time spent in the light compartment of the light/dark test

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Studies on the synergistic effects of plant extracts with each other (polyherbal formulations) or with synthetic drugs could lead to more effective treatments with lower doses and fewer side effects

However, novel advances have led to more stable and orally bioavailable preparations that may augment this peptides already considerable therapeutic potential, especially as it affects the GI tract