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An overactive cytokine response is associated with chronic inflammatory conditions and was a notable factor in severe COVID-19 cases, where studies found that many seriously ill patients had significantly depleted glutathione stores
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The closest safety dataset is the Increlex (mecasermin) clinical program , which followed 71 pediatric patients with severe primary IGFD on twice-daily SubQ rhIGF-1 for a mean of 3.9 years (some patients up to 11.5 years)
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