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Prolonged use of binders without proper timing and supplementation can lead to severe nutrient deficiencies, particularly of fat-soluble vitamins (A, D, E, and K), magnesium, zinc, and essential fatty acids, which are already often depleted in chronic illness patients

Hypothyroidism and obesity: An intriguing link

Relationships and romance These positive side-effectsreduced food noise, increased self-esteem, and more energyhave translated into better relationships with their friends and family for many users

Those are two different kinds of evidence, and neither establishes that one route produces greater systemic exposure in a living organism