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(Endocrinology, 2010), demonstrated a strong species-dependent effect: In rodents: High GLP-1 receptor expression in thyroid C-cells Strong cAMP signaling activation Persistent stimulation leads to tumor formation In humans and primates: Minimal or absent functional GLP-1 receptor expression in C-cells No meaningful calcitonin elevation under therapeutic exposure No observed C-cell proliferation in long-term studies Even exposure levels far exceeding clinical doses failed to reproduce rodent-like thyroid effects in primate models
Retrieved from Aging and Frailty Study Eurekaselect
AmphibiaWeb) continuing to list the species as Rana clamitans
The medications' effects on appetite regulation and satiety might also play an indirect role, as some individuals report that reduced overall appetite extends to diminished desire for alcohol
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