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Weight Loss in Obese Adults In a 48-week phase 2 trial published in The New England Journal of Medicine , retatrutide demonstrated unprecedented weight loss efficacy in adults with obesity
This is another reason why phentermine shouldnt be used on a long-term basis: the brain gets used to a free boost of dopamine on demand and starts demanding more, sometimes with devastating effects such as dependence, overdose, and the possibility of transfer addictions
Similarly, semaglutide for weight management is typically provided within specialist weight management services and usually for up to 2 years, in accordance with NICE TA875
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