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Reclining slows digestion further and increases the chance that stomach contents create pressure in the wrong direction

Pharmacol Ther 113(3):546593 Dozio E, Vianello E, Malavazos AE, Tacchini L, Schmitz G, Iacobellis G et al (2019) Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate cardiovascular risk

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Still, the MHRA makes these determinations on a case-by-case basis when complaints are received or manufacturers seek advice