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(PubMed) Berezhnoy G, Laske C, Trautwein C
About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted
Until more comprehensive studies are available, its safest to postpone any plans to use this peptide if you are pregnant, planning to become pregnant, or breastfeeding
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