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However, excessively high ROS levels can cause severe damage to nucleotides, proteins, cell membranes, and organelles, ultimately leading to cell death
2014;16(12):1180-1191.[DOI] 74
The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage
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