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Neurology 75 , 9971002 (2010)
Though more research is required to determine this relationship, data from the Kronos Early Estrogen Prevention Study (KEEPS) found that women who received the estrogen patch had the highest maintenance of brain volume in the dorsolateral prefrontal cortexthe part of the brain that helps with memory, thinking, planning, and reasoning
Beyond absolute reductions in body weight, improvements in insulin sensitivity appear to be a key mechanistic link between metabolic interventions and attenuation of systemic inflammation
32,43 Moreover, because of the heterogeneous nature of tumors, there are considerable variations in NADPH-related processes in different tumors, for example, the main pathways of glutamine metabolism in the context of PDAC are different from the previous prevailing view as informed by studies of other cancers, 159,192 indicating the need for careful analyses of individual characteristics among cancers for establishing individualized precision therapy
