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For women struggling with midlife weight gain despite reasonable efforts, they can make a real difference
The overwhelming majority of episodes were manageable within continued treatment
Controlled trials should also assess whether microbiota-directed interventions, including fiber, prebiotics, probiotics, synbiotics, polyphenol-rich diets, and structured lifestyle programs, can enhance tirzepatide efficacy or support long-term weight maintenance
However, high-calorie carb-loading protocols defeat the purpose of appetite suppression
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