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Just the levels of quinine found in tonic water may cause potentially fatal immunologically-mediated hypersensitivity reactions, basically like allergic reactions, where it interacts with antibodies to trigger autoimmune reactions that can include chills, fever, a drop in blood pressure, painful bluish discoloration of the hands and feet, and clotting within your blood vessels

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Presented for research literature review only Grover PL (1982)