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Identification of vitamin B12 as a modulator of LRRK2 activity constitutes a huge step forward because it is a neuroprotective vitamin in animal models and has a mechanism unlike that of currently existing inhibitors, Iban Ubarretxena, director of the Biofisika Institute and co-author of the study, said in a press release

Supplementary material The Supplementary Material for this article can be found online at: References 1 AdachiS.KawamotoT.OtsukaM.TodorokiT.FukaoK

En ese marco, los derivados de quinolinio como 5-Amino-1MQ (5-amino-1-metilquinolinio) emergieron como inhibidores de molcula pequea capaces de bloquear la metilacin de nicotinamida sin las limitaciones de biodisponibilidad de agentes de mayor tamao