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Patients with chronic kidney disease, dialysis needs, or advanced liver conditions should only consider IV infusion under close medical supervision

The ORIGIN trial showed that insulin glargine neither increased nor decreased cardiovascular events compared to standard care

Conclusion In conclusion, the association between GLP 1RAs and an increased risk of depression revealed in this study provides crucial evidence for research on the mental safety of this class of drugs and raises new concerns for clinical practice in the context of their increasingly widespread use

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