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These pollutants and lifestyle factors generate free radicals within the body

However, once the homeostasis of these metal ions is disrupted, either depletion or accumulation, they can affect the activity of enzymes involved in neurodegenerative diseases since they serve as important cofactors for enzymes

Proteins containing nitrotyrosine residues have been detected in various pathogenic conditions, such as diabetes, hypertension, and atherosclerosis, all linked with promoted oxidative stress, including increased formation of ONOO

Cigarette smoke exposure leads to follicle loss via an alternative ovarian cell death pathway in a mouse model