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Typically, health insurers do not provide coverage for these medications, particularly when prescribed off-label for conditions such as SUD that currently lack FDA approval (National Association of Insurance Commissioners, 2024)
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Blood Sugar Effects Both medications improve glucose metabolism: Liraglutide: HbA1c reduction of 0.5-1.0% at weight loss doses Originally developed for diabetes (Victoza) Modest glucose benefits at Saxenda doses Semaglutide: HbA1c reduction of 1.0-1.8% at diabetes doses Greater glucose improvement than liraglutide Significant benefit for prediabetes and diabetes For patients with diabetes or prediabetes, semaglutide provides greater metabolic benefit
Blood tests may show increased bilirubin, alkaline phosphatase, GGT, ALT, AST, or white blood cells when biliary obstruction or inflammation is present
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