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both antibiotic use and germ-free conditions suppress the expression of CYP7A1 and CYP27A1, key enzymes involved in BA production based on animal mechanistic studies (Chiang and Ferrell, 2019)

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Studies show that low levels of serum melatonin are related to poor prognosis in HCC, especially after liver transplantation, which suggests that melatonin could impact tumor development and survival [94]