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Disentangling these effects requires controlled studies that have not yet been conducted

Future immunotherapies will therefore benefit from the study of the interplay between LECs and the immune system in pathological conditions, and from understanding the molecular and cellular bases underlaying the reprogramming that these cell types may undergo to provide an immunosuppressive niche in primary tumors and TDLNs

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This timeframe allows assessment of individual response, opportunity to adjust dosing, and generation of meaningful results without committing to an extended protocol