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Weight loss during weeks 1-2 typically ranges from 2-4 pounds, though some people see more dramatic drops due to water weight reduction

In a direct comparison, the dual agonists DA4-JC and DA5-CH were able to cross the BBB much better than standard GLP-1 receptor agonists, such as exendin-4, liraglutide, and semaglutide (Zhang et al., 2020)

However, individuals with pre-existing health conditions, hormonal disorders, or those taking medications should consult their healthcare provider before starting any peptide therapy

But some clinicians say that prescribing these drugs is about balancing risk and benefit, not about a person's body size