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Potential endpoints include: Endothelial-cell viability Migration Tube-formation assays Growth-factor-associated measurements Matrix interaction Cell-junction markers Gene-expression changes Structural imaging Tube formation in a culture model does not independently establish blood-vessel growth, tissue repair, or clinical benefit
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In this work, heterogeneity is explicitly incorporated at the mechanistic level by stratifying cancers according to the functional integrity of core apoptotic regulators rather than tissue of origin
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