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The observed PD-L1 upregulation was shown to be reliant upon the JAK/STAT pathway upon IFN- binding the IFN- receptor
By contrast, routine initiation is generally not indicated for lean PCOS or for patients with low cardiometabolic risk, except in selected circumstances (e.g., specific metabolic indications) or within research protocols
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The side chain structure allows for once-weekly dosing which is a big convenience compared to daily medications
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