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Risk Factors for Cortical, Nuclear, Posterior Subcapsular, and Mixed Lens Opacities: The Los Angeles Latino Eye Study

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Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases

Conditioned media from silica-treated macrophages (MCM) was sufficient to activate the NLRP3 inflammasome, PFKFB3-driven glycolysis, and lactate-mediated histone lactylation in cultured fibroblasts