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Since the circadian melatonin cycle has been identified in the blood of every mammalian species where it has been examined (with the possible exception of some mice which genetically lack the enzymatic machinery to synthesize melatonin in the pineal gland), it was a reasonable assumption that the synchronizing actions of melatonin on the SCN is a result of the variation in day:night blood melatonin levels (44)

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This break serves two purposes: it prevents melanocortin receptor desensitization (diminishing returns), and it creates a window for thorough mole monitoring without the confounding variable of active melanocyte stimulation

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H.JiangA

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