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The remaining ten trials compared tirzepatide with placebo, GLP-1 RA (other than semaglutide), basal insulin, prandial insulin or varying doses of tirzepatide
Semaglutide slows gastric emptying, which could theoretically delay the absorption of oral medications
Metformin works primarily by reducing hepatic glucose production (the amount of glucose released by the liver), improving insulin sensitivity in peripheral tissues, and modestly enhancing glucose uptake in muscles
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