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Hypoglycaemia This is a rare and serious side effect
Any of these shifts can contribute to headaches, and they often overlap
A pre-bed dose is timed to reinforce that natural nocturnal pulse, which is why the pre-bed slot is the one most consistently kept even in a once-daily schedule
Vidal-Torres A, Fernndez-Pastor B, Carceller A, Vela JM, Merlos M, Zamanillo D (2019) Supraspinal and peripheral, but not intrathecal, (1)R blockade by S1RA enhances morphine antinociception
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