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The compound shows activity at extremely low concentrations in laboratory settings, sometimes as little as 0.01 nanomolar
10.1165/rcmb.2024-0176TR Summary Keywords NADPH oxidase, epithelial sodium channel, capillary endothelium, alveolar-capillary barrier function, pneumonia, TNF, TIP peptide Citation Eaton DC, Romero MJ, Matthay MA, Hamacher J, Advani A, Wolf A, Abu Mraheil M, Chakraborty T, Stepp DW, Belin de Chantemle EJ, Kutlar A, Kraft F, Zeitlinger M, Kranke P, Frank S, Su Y, Verin AD, Fulton DJR, Ushio-Fukai M, Fukai T and Lucas R (2025) Endothelial ENaC as a repressor of oxidative stress and a guardian of lung capillary barrier function in bacterial and viral pneumonia
For researchers using the research peptide catalog to investigate oxidative stress pathways, the AEDG sequences multi-pathway research profile spanning telomerase, melatonin, and antioxidant gene regulation makes it a particularly informative compound for studying the interconnections between aging hallmarks
ROS and the DNA damage response in cancer
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