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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

Most cancers develop over years to decades, and trial durations of 1-2 years may be insufficient to identify slowly developing malignancies

It should be given in a clean, clinical setting to reduce the small risk of infection or irritation at the injection site

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