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As a reference, recombinant IGF-1 injections have a half-life of under 6 hours when given subcutaneously as a treatment of growth failure and slower development of children due to poor IGF-1 levels

If you stop tirzepatide and wait two weeks (roughly four half-lives) before starting retatrutide, the previous medication will have largely cleared, and you are starting closer to baseline

While patients and health care professionals may look to unapproved versions of GLP-1 drugs, including semaglutide and tirzepatide, as an option for weight loss, this can be risky as unapproved versions do not undergo FDAs review for safety, effectiveness, and quality before they are marketed (FDA)

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