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The average 4 to 6 pound reduction over 26 to 78 weeks is statistically significant but smaller than what most patients expect from "semaglutide." For context, the STEP 1 trial of injectable semaglutide 2.4 mg weekly showed average weight loss of 33 pounds over 68 weeks in patients without diabetes
Where Research Is Heading / What to Watch For Larger RCTs in non-diabetic or prediabetic populations specifically targeting cognitive decline or dementia as endpoints
Phentermine combination Some patients ask about combining phentermine with tirzepatide
Suitable candidates include patients with a BMI of 30 or above, or those with a BMI of 27 or above with one weight-related condition
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