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It works by simultaneously activating the glucose-dependent insulinotropic polypeptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1R), which results in increased insulin release, decreased glucagon secretion, reduced hunger, delayed gastric emptying, and significant weight loss

So people who have not just excess body weight, but serious metabolic comorbidities really can, um, can benefit

Retatrutide is an effective triple-receptor agonist that works by slowing stomach emptying, regulating appetite, and boosting energy metabolism

A specialized transporter for the uptake of biotin and pantothenic acid was identified in cultured cells derived from the lining of the colon, suggesting that humans may be able to absorb pantothenic acid and biotin produced by intestinal bacteria (39)