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Manufacturers calibrate the in-use window to keep hydrolysis below the threshold where potency drops more than 5%
Although due to high demand, there were some shortages in Quebec in 2023 and 2024, but over the last year or so, stock supplies of the medication appear to have restabilized
The medication also promotes weight loss typically 3-6 kg in patients with type 2 diabetes at the doses used for diabetes treatment which itself may confer cardiovascular benefits through reduced cardiac workload and improved metabolic parameters
Some individuals, particularly those with certain medical conditions or nutrient deficiencies, may have lower glutathione levels
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