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These include: Inappropriate dosing or frequency Lack of proper diagnosis and monitoring Non-sterile injection technique increasing infection risk Absence of medical supervision for adverse reactions Financial cost without clinical benefit Patients should report any suspected adverse reactions to B12 injections via the MHRA Yellow Card scheme

What neither camp disputes is the core evidentiary finding: across all seven compounds reviewed over the two days, there are no large, controlled, randomized human trials establishing safety or efficacy for the proposed injectable routes