Transitioning from weight loss to maintenance Determining goal weight achievement: Lost 10-12% body weight (cagrilintide alone) Lost 15-25% body weight (CagriSema) Weight stable for 4-8 weeks Satisfied with current weight Ready to focus on maintenance Maintenance dose options comparison: Option 1: Continue same dose Keep cagrilintide at 2.4mg weekly Ensures no regain Most conservative approach Highest cost Option 2: Reduce dose slightly Decrease to 1.8-2.0mg weekly Monitor weight for 4 weeks If stable, maintain If gaining, increase back 20-25% cost savings Option 3: Try every 10 days Instead of weekly, inject every 10 days Effectively 30% dose reduction Some maintain weight this way Requires close monitoring Recommendation: Try Option 2 first (reduce to 1.8-2.0mg)

What this means in practice: If youre on warfarin and start Mounjaro, your INR should be monitored more frequently during the initial months of treatment typically every one to two weeks rather than monthly, until your levels stabilise at your new weight
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However, it is a decision that requires careful consideration of the efficacy and treatment plan for your chosen medication Mounjaro, however, contains tirzepatide, which has a dual action, binding to both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, enhancing its effects on weight loss and blood sugar control